St. John's wort extract
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Basic information
Product Name: St. John's wort extract
Appearance: Brown to yellow powder or granular
Standard Packing: 25kg/drum
Solubility: Dissolve in water and ethanol.
Source & Botanical Characteristics:
Scientific Name: Hypericum perforatum L. (Hypericaceae family)
Common Names: St. John's wort, perforate St. John's wort
Medicinal Parts: Aerial parts (flowers, leaves, stems) during flowering season
Key Identification Features:
Small yellow flowers with black glandular dots (visible under light)
Opposite leaves that release red sap when crushed (hypericin)
Standard: CP2020,JP,Customer Made
Core Active Components
1 .Characteristic Compounds
Class |
Representative Compounds |
Content Range |
Bioactivity |
Naphthodianthrones |
Hypericin |
0.1-0.3% |
Antiviral (photoactivated HIV inhibition) |
Pseudohypericin |
0.05-0.2% |
Antidepressant (reversible MAO-A inhibition) |
|
Flavonoids |
Hyperoside |
0.5-2.0% |
Antioxidant (ROS scavenging) |
Phloroglucinols |
Hyperforin |
2-5% |
Antidepressant (SSRI-like effect) |
Essential Oils |
α-Pinene |
0.3-1.5% |
Anti-inflammatory (COX-2 inhibition) |
2. Synergistic Effects
Hypericin + hyperforin: 3× greater antidepressant efficacy (HAM-D scores)
Hyperoside + zinc: 2× enhanced neuroprotection
High Purity
100% Natural
Compliant with standards
Stable supplying
Quality ensured
Versatile Applications
Antidepressant Mechanisms
Neurotransmitter modulation:
Inhibits 5-HT/NE/DA reuptake (hyperforin IC50=0.05 μM)
Downregulates β-adrenergic receptor density (chronic stress models)
Clinical Data: 900mg/day ×6 weeks ≈ fluoxetine efficacy (50% ↓HAM-D scores)
Antiviral Effects
In Vitro: IC50=0.01 μg/mL against HSV-1 (requires visible light activation)
Neuroprotection
Inhibits β-amyloid aggregation (Alzheimer's models)
↑35% BDNF expression in hippocampus
Application Fields Green max
1. Pharmaceuticals:
Antidepressants: Sustained-release capsules (reduced dosing frequency)
Antiviral topicals: 0.3% hypericin cream (herpes simplex treatment)
2. Functional Foods:
Mood support: Combined with saffron (↑5-HT levels)
Cognitive enhancement: With phosphatidylserine (↑25% memory)
3.Cosmetics:
Phototherapy: Hypericin PDT (90% C. acnes eradication)
Anti-aging: 0.5% hyperforin (MMP-1 inhibition)
Structural Optimization
Hypericin liposomes: 10× ↓phototoxicity while retaining antiviral activity
Synthetic Biology
Yeast-engineered hyperforin production (lab yield: 0.3g/L)
New Clinical Applications
Fibromyalgia: Phase II shows 30% ↓pain scores
Usage Guidelines
1. Precision Dosing
Application |
Daily Dose |
Duration |
Optimal Combinations |
Mild depression |
900 mg |
≥6 weeks |
Vitamin B6 |
Seasonal affective disorder |
600 mg |
3 winter months |
Light therapy |
Antiviral topical |
0.1-0.3% |
Acute phase |
Sun avoidance |
2. Precautions
Avoid sunlight exposure (photosensitivity lasts 7 days)
Use contraception during treatment (drug interactions)
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