Salvia miltiorrhiza extract
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Basic information
Product Name: Salvia miltiorrhiza extract
Appearance: Red brown to brown powder or granules
Standard Packing: 25kg/drum
Solubility: Dissolve in water and ethanol.
Source & Botanical Characteristics:
● Scientific Name: Salvia miltiorrhiza Bunge
● Aliases: Red sage, Blood root (brick-red cross-section indicates high quality)
● Medicinal Parts: Taproot (requires ≥3 years of cultivation for optimal potency)
● Geographical Indications:
Sichuan Zhongjiang ("Chuan Danshen" – highest tanshinone content)
Shandong Juxian ("Shan Danshen" – rich in salvianolic acids)
● Key Identification Traits:
Square stems with opposite pinnate leaves
Purple-red root bark with radial striations
Standard: CP2020, JP, Customer Made
Core Active Components
1. Major Bioactive Compounds
|
Component Category |
Representative Compounds |
Content Range |
Primary Effects |
|
Tanshinones |
Tanshinone IIA |
0.3-0.8% |
Cardiovascular protection (antiplatelet) |
|
Phenolic Acids |
Salvianolic acid B |
3-8% |
Antioxidant (free radical scavenging) |
|
Polysaccharides |
Acidic heteropolysaccharide (SMWP) |
5-12% |
Immunomodulation (lymphocyte proliferation) |
|
Essential Oils |
β-Eudesmol |
0.1-0.5% |
Neuroprotection (microglia inhibition) |
|
Amino Acids |
Arginine |
1-3% |
Microcirculation improvement (NO production) |
2. Synergistic Effects:
● Tanshinone IIA + Salvianolic acid B: Myocardial ischemia protection ↑50%
● Polysaccharides + Zinc: Wound healing speed ↑30%
High Purity
100% Natural
Compliant with standards
Stable supplying
Quality ensured
Versatile Applications
Application Fields Green max
1. Pharmaceutical Uses:
● Cardiology: Coronary heart disease, angina (Danshen Dripping Pills)
● Neurology: Alzheimer's disease adjuvant therapy
2. Functional Foods:
● Cardioprotective capsules: Improves myocardial blood supply
● Antioxidant beverages: ORAC value ≥5000 μmol TE/g
3. Cosmetics:
● Anti-redness serums: Reduces capillary fragility
● Anti-aging creams: Inhibits MMP-1 expression
Future R&D Directions
1. Technological Innovations:
● Nano-liposome encapsulation (5× tanshinone bioavailability)
● Synthetic biology production (yeast-expressed salvianolic acid B)
2. Emerging Applications:
● COVID-19 adjuvant therapy (inhibits cytokine storm)
● Sports medicine: Alleviates muscle ischemia-reperfusion injury
Safety Profile
1. Toxicology Data:
● Acute toxicity: LD50 >15g/kg (practically non-toxic)
● Chronic toxicity: No organ damage in 6-month rat studies
2. Contraindications:
● Caution in bleeding disorders
● Requires INR monitoring with warfarin co-administration
Usage Guidelines
1. Recommended Dosage
|
Application |
Formulation |
Concentration |
Duration |
|
Cardiovascular care |
Oral tablets |
200-400mg/day |
3-6 months |
|
Skin repair |
Topical gel |
1-3% |
4-8 weeks |
|
Neuroprotection |
IV injection |
10-20mg/kg |
2-4 weeks |
2. Precautions:
● Injections may cause transient facial flushing
● Avoid high-dose combinations with anticoagulants
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