English
English French German Portuguese Spanish Russian Japanese Korean Arabic Irish Greek Turkish Italian Danish Romanian Indonesian Czech Afrikaans Swedish Polish Basque Catalan Esperanto Hindi Lao Albanian Amharic Armenian Azerbaijani Belarusian Bengali Bosnian Bulgarian Cebuano Chichewa Corsican Croatian Dutch Estonian Filipino Finnish Frisian Galician Georgian Gujarati Haitian Hausa Hawaiian Hebrew Hmong Hungarian Icelandic Igbo Javanese Kannada Kazakh Khmer Kurdish Kyrgyz Latin Latvian Lithuanian Luxembou.. Macedonian Malagasy Malay Malayalam Maltese Maori Marathi Mongolian Burmese Nepali Norwegian Pashto Persian Punjabi Serbian Sesotho Sinhala Slovak Slovenian Somali Samoan Scots Gaelic Shona Sindhi Sundanese Swahili Tajik Tamil Telugu Thai Ukrainian Urdu Uzbek Vietnamese Welsh Xhosa Yiddish Yoruba Zulu Kinyarwanda Tatar Oriya Turkmen Uyghur
Leave Your Message
Pterostilbene
Natural API
Pterostilbene.jpg
CAS No.​537-42-8.jpg

Pterostilbene

Pterostilbene (CAS: 537-42-8) is a natural stilbenoid compound primarily found in blueberries, sandalwood, and grapes. As a methylated derivative of resveratrol, it exhibits superior antioxidant, anti-inflammatory, and anti-aging​ activities. The U.S. FDA classified it as a dietary supplement (GRAS) in 2022, while the EU ESFA approved it as a novel food ingredient (2021/C 456/03). China's National Health Commission included it in the food additive catalog (GB 2760-2023) in 2023.

Product Name: Pterostilbene

IUPAC Name: (E)-3,5-Dimethoxy-4'-hydroxystilbene

CAS No.​: 537-42-8

Molecular Formula: C₁₆H₁₆O₃

    Contact us
    product details
    product description

    description1

    description2

    CAS No

    Basic information

    Product Name: Pterostilbene

    IUPAC Name: (E)-3,5-Dimethoxy-4'-hydroxystilbene

    CAS No.​:  537-42-8

    Molecular Formula: C₁₆H₁₆O₃

    Physicochemical Properties:

    Parameter

    Value/Description

    ​Appearance​

    White powder

    ​Melting Point​

    89–91°C

    ​Solubility​

    0.05 mg/mL in water; >50 mg/mL in ethanol/DMSO

    ​logP​

    3.5 (high lipophilicity)

    ​pKa​

    9.2 (phenolic OH)

    ​Stability​

    Light-sensitive; stable at pH 5–8

    Quality Standard: CP2020,JP,Customer Made

    Specification

    Test Items

    Standard

    Pterostilbene (CAS: 537-42-8)

    98% by HPLC

    Loss on drying

    ≤0.5%

    Residue on ignition

    ≤0.5%

    Key Features

    index_10-7

    Structural Advantage

    3,5-Dimethoxy modification (4× higher bioavailability than resveratrol).
    index_10-7

    Multi-Target Action

    Simultaneously activates SIRT1, inhibits NF-κB and mTOR pathways.
    index_10-7

    Clinical Advantages

    3× higher blood-brain barrier permeability than resveratrol.

    Pharmacological Mechanisms

    1.Molecular Target Network

    Molecular Target Network

    2.Pharmacokinetics

    Absorption

    80% oral bioavailability (low first-pass effect).

    Distribution

    Brain/plasma ratio=2:1 (significant BBB penetration).

    Metabolism

    Hepatic CYP2D6-mediated hydroxylation (active metabolites).

    Excretion

    Primarily urinary (70% clearance in 24h).

    Clinical Applications

    Indications & Protocols​

    Condition​

    ​Regimen​

    ​Evidence​

    ​Aging Intervention​

    100 mg/day ×6 months

    ↑20% telomerase activity*

    ​Mild Cognitive Impairment​

    50 mg bid (Phase II)

    ↑3 ADAS-cog points

    ​Type 2 Diabetes​

    150 mg/day

    ↓0.7% HbA1c

    *Randomized controlled trial (n=180)

    Special Populations​

    Hepatic Impairment: Reduce dose 30% (Child-Pugh B).

    Pediatrics: Limited safety data (research only).

    Dosage and Administration

    1. Formulations​

    Softgel Capsules: 50 mg/capsule (MCT oil carrier).

    Sublingual Tablets: 20 mg/tablet (rapid absorption).

    Injection: 10 mg/mL (dilute in saline).

    2. Dosing Guidelines

    Use​

    ​Dose​

    ​Duration​

    ​Anti-Aging​

    50–150 mg/day

    Long-term

    ​Neuroprotection​

    50–100 mg/day

    6–12 months

    ​Metabolic Improvement​

    100–200 mg/day

    3–6 months

    Safety Evaluation

    1. Adverse Reactions

    ​System​

    ​Incidence​

    ​Manifestations​

    ​Gastrointestinal​

    5%

    Mild nausea

    ​Neurological​

    2%

    Transient headache

    ​Hypersensitivity​

    0.1%

    Rash

    2. Contraindications & Interactions​

    ● Absolute CI:
    Stilbenoid allergy.
    Pregnancy (high-dose embryotoxicity in animals).

    ● Cautions:CYP2D6 inhibitors (e.g., fluoxetine): ↑2× plasma concentration.

    Research Progress Green max

    Novel Formulations​
    Nanoemulsions: ↑Oral bioavailability to 90%.
    Transdermal Patches: For localized anti-aging (Patent WO202311688).

    New Indications
    Post-COVID Syndrome: Inhibits cytokine storm (↓60% IL-6).
    Non-Alcoholic Fatty Liver: Reduces fibrosis (↓40% collagen in animals).

    Pterostilbene

    Please Send me email and you can get more what you want.

    Such as product of  Price, Specification, MOA, MSDS, Flow Chart, Packing details, Shipping Term, Payment Term, after Sale service and so on.

    Our experts will solve them in no time.