Gynostemma extract
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Basic information
Product Name: Gynostemma extract
Appearance: Brown to yellow powder or granular
Standard Packing: 25kg/drum
Solubility: Dissolve in water and ethanol.
Source and Botanical Characteristics:
Scientific Name: Gynostemma pentaphyllum (Thunb.) Makino
Aliases: Jiaogulan, Seven-leaf Vine, Miracle Grass
Medicinal Parts: Whole plant (primarily leaves and stems)
Distribution: Southern China, Japan, Southeast Asia
Key Features:
Palmately compound leaves, typically with 5-7 leaflets (occasionally 9)
Climbing vine with small yellow-green flowers in summer
Standard: CP2020,JP,Customer Made
Core Active Components
1. Characteristic Compounds
Category |
Representative Compounds |
Content Range |
Biological Activity |
Saponins |
Gypenosides |
2-8% |
Antioxidant, lipid-lowering (PPARγ activation) |
Ginsenosides Rb1/Rb3 |
0.5-1.2% |
Neuroprotection (↑BDNF) |
|
Flavonoids |
Rutin |
0.3-1.5% |
Anti-inflammatory (COX-2 inhibition) |
Polysaccharides |
Gynostemma Polysaccharides (GPPS) |
5-15% |
Immunomodulation (macrophage activation) |
Amino Acids |
Arginine |
1.2-3.0% |
Improves microcirculation (↑NO production) |
2. Synergistic Effects
Gypenoside XLIX + Zinc: 3× enhancement of insulin sensitivity
Polysaccharides + Selenium: Synergistic increase in NK cell activity
High Purity
100% Natural
Compliant with standards
Stable supplying
Quality ensured
Versatile Applications
Hypoglycemic Mechanism
Insulin Sensitization: Activates AMPK/PPARγ pathway (EC50=5 μM)
Clinical Data: 1,000 mg/day × 12 weeks, HbA1c ↓1.2% (comparable to metformin)
Anti-Aging Effects
Animal Study: Nematode lifespan extended by 35% (100 μg/mL treatment)
Hepatoprotection
Reduces ALT/AST (alcoholic liver injury model, outperforms silymarin)
Inhibits hepatic stellate cell activation (↓TGF-β1 by 50%)
Application Fields Green max
1.Pharmaceutical Sector:
Antidiabetic Drugs: Combined with chromium complexes (enhances bioavailability)
Liver Protection Tablets: Cost-effective alternative to silymarin
2.Functional Foods:
Anti-Fatigue: Paired with Eleutherococcus senticosus (↑exercise endurance by 40%)
Immune Boosting: Combined with lentinan (↑IgG by 25%)
3. Cosmetics:
Anti-Wrinkle Serums: 0.5% gypenosides (↑collagen synthesis 3×)
Sun Damage Repair: Inhibits UVB-induced MMP-1
Structural Modification
Acetylated gypenosides (improves blood-brain barrier penetration)
Synthetic Biology
Yeast expression system for Gypenoside XLIX (lab yield: 0.5 g/L)
New Indications
Alzheimer’s Disease: Phase I shows ↓Aβ42 by 30%
Usage Guidelines
Precision Dosage
Purpose |
Daily Dose |
Duration |
Recommended Combinations |
Diabetes Support |
1,000-1,500 mg |
≥3 months |
Chromium picolinate |
Anti-Aging |
600 mg |
Long-term |
NAD+ precursors |
Liver Protection |
800 mg |
1 hour pre-alcohol |
Silymarin |
Precautions
Avoid during pregnancy (insufficient safety data)
Discontinue 2 weeks before surgery (antiplatelet effect)
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