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Deoxycholic acid
Cholic acid series Products
Deoxycholic acid.jpg
CAS No.​ 83-44-3.jpg

Deoxycholic acid

Deoxycholic acid (DCA, CAS: 83-44-3) is a secondary bile acid with the chemical formula C₂₄H₄₀O₄ and molecular weight 392.58 g/mol. Formed through 7α-dehydroxylation of primary bile acids (e.g., cholic acid) by gut microbiota, it holds dual significance in metabolic regulation and medical aesthetics. As the first FDA-approved injectable lipolytic drug (Kybella®, 2015), its serum levels (normal range: 0.5-5.0 μmol/L) are recognized in the 2023 Gastroenterology guidelines as key indicators of gut-liver axis function.

Product Name: Deoxycholic acid

CAS No.​: 83-44-3

Molecular Formula: C₂₄H₄₀O₄

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    CAS No

    Basic information

    Product Name: Deoxycholic acid

    CAS No.​: 83-44-3

    Molecular Formula: C₂₄H₄₀O₄

    IUPAC Name: (3α,5β,12α)-3,12-Dihydroxycholan-24-oic acid

    Appearance & Solubility:

    Property​

    ​Specification​

    Appearance

    White needle-like crystals

    Melting Point

    171-174°C

    Water Solubility

    0.08 mg/mL (25°C)

    Quality Standard: CP2020,JP,Customer Made

    Specification

    Test Items

    Standard

    Deoxycholic acid(CAS: 83-44-3)

    99%

    Key Features

    index_10-7

    Structural Uniqueness

    Retains bile acid backbone but lacks 7α-hydroxyl (↑30% lipophilicity)

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    Dual Functionality

    Physiological (<10 μM): Enhances fat absorption

    High concentration (>100 μM): Induces adipocyte lysis (for fat reduction)

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    Pharmacopoeial Status

    Monographed in USP-NF, EP 11.0, and ChP 2020

    Pharmacological Mechanisms

    1. Lipolytic Action

    Pharmacological Mechanisms2

    2. Molecular Targets​

    ​Target​

    ​Effect​

    ​EC50​

    Cell Membrane

    Physical lysis

    1.5 mM

    TGR5 Receptor

    ↑Mitochondrial activity

    50 μM

    FXR Receptor

    Inhibits lipogenic genes

    10 μM

    Clinical Applications​

    competitiveness2
    competitiveness
    Benefits
    Aesthetic Indications

    Submental Fat:
    1-2 mL injections (10 mg/mL) per session
    Requires 4-6 sessions (≥1-month intervals)
    competitiveness2
    competitiveness
    Benefits
    Metabolic Disorders

    Bile Acid Diarrhea:Cholestyramine to bind excess DCA (3g/dose, bid)

    Dosage & Administration

    Injection Protocols​

    ​Indication​

    ​Concentration​

    ​Volume/Site​

    ​Max Dose/Session​

    Double Chin

    10 mg/mL

    0.2 mL/site

    ≤10 mL

    Abdominal Fat*

    20 mg/mL

    0.5 mL/site

    ≤50 mL

    *Investigational use only

    Safety Profile

    Adverse Effects​

    ​Reaction​

    ​Incidence​

    ​Management​

    Injection Site Edema

    72%

    Ice + compression

    Nerve Injury

    <0.1%

    Immediate discontinuation

    Contraindications​

    Infection at injection site

    Coagulation disorders

    Research Progress Green max

    1.  Novel Formulations​

    Nanoemulsified DCA:100nm particles (↓60% pain perception)

    Sustained-Release Microspheres:Maintains effective concentration for 14 days (animal models)

    2.Anticancer Research​

    Mechanism:Induces hepatocellular carcinoma apoptosis via ROS (IC50=200 μM)

    Deoxycholic acid

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