English
English French German Portuguese Spanish Russian Japanese Korean Arabic Irish Greek Turkish Italian Danish Romanian Indonesian Czech Afrikaans Swedish Polish Basque Catalan Esperanto Hindi Lao Albanian Amharic Armenian Azerbaijani Belarusian Bengali Bosnian Bulgarian Cebuano Chichewa Corsican Croatian Dutch Estonian Filipino Finnish Frisian Galician Georgian Gujarati Haitian Hausa Hawaiian Hebrew Hmong Hungarian Icelandic Igbo Javanese Kannada Kazakh Khmer Kurdish Kyrgyz Latin Latvian Lithuanian Luxembou.. Macedonian Malagasy Malay Malayalam Maltese Maori Marathi Mongolian Burmese Nepali Norwegian Pashto Persian Punjabi Serbian Sesotho Sinhala Slovak Slovenian Somali Samoan Scots Gaelic Shona Sindhi Sundanese Swahili Tajik Tamil Telugu Thai Ukrainian Urdu Uzbek Vietnamese Welsh Xhosa Yiddish Yoruba Zulu Kinyarwanda Tatar Oriya Turkmen Uyghur
Leave Your Message
Cytisine
Natural API
Cytisine.jpg
Thermopsis.jpg

Cytisine

Cytisine (CAS: 485-35-8) is a tetracyclic quinolizidine alkaloid extracted from the seeds of Cytisus laburnum (Fabaceae family). As a plant-derived partial agonist of nicotinic acetylcholine receptors (nAChRs), its structure resembles nicotine but with lower toxicity. Approved by the EU as a smoking cessation drug (brand name Tabex®), it was recently listed by WHO (2023) as a first-line smoking cessation aid.

Product Name: Cytisine

IUPAC Name: (1R,5S)-3,4,5-Trihydroxy-1,5-methano-1H-pyrido[1,2-a][1,5]diazocin-8-one

CAS No.​: 485-35-8

Molecular Formula: C₁₅H₁₉NO₃

    Contact us
    product details
    product description

    description1

    description2

    Cytisine

    Basic information

    Product Name: Cytisine

    IUPAC Name: (1R,5S)-3,4,5-Trihydroxy-1,5-methano-1H-pyrido[1,2-a][1,5]diazocin-8-one

    CAS No.​: 485-35-8

    Molecular Formula: C₁₅H₁₉NO₃

    Physicochemical Properties:

    Parameter

    Value/Description

    ​Appearance​

    white powder

    ​Melting Point​

    198-201°C (decomposition)

    ​Solubility​

    85 mg/mL in water (5× improvement)

    ​logP​

    -0.3 (high hydrophilicity)

    ​pKa​

    9.2 (tertiary amine)

    Quality Standard: CP2020,JP,Customer Made

    Specification

    Test Items

    Standard

    Cytisine (CAS: 485-35-8)

    98% by HPLC

    Loss on drying

    ≤1.0%

    Total of other impurities

    ≤1.5%

    Key Features

    index_10-7

    Natural Source

    1.5-3% in Cytisus laburnum seeds.
    index_10-7

    Mechanism

    High selectivity for α4β2 nAChRs (Ki=0.5 nM), potency 1/5 of nicotine.
    index_10-7

    Cost-Effectiveness

    1/10 the price of varenicline, full course <$50.

    Pharmacological Mechanisms

    1.Molecular Target Network

    Pharmacological Mechanisms2

    2. Pharmacodynamic Profile

    Absorption

    75% oral bioavailability (+15% vs. original).

    Distribution

    Brain/plasma ratio 1.2:1.

    Metabolism

    Hepatic CYP2D6 hydroxylation.

    Excretion

    Renal (90% clearance in 12h).

    Clinical Applications​

    Indications & Protocols​

    ​Condition​

    ​Dose​

    ​Efficacy​

    ​Nicotine Dependence​

    2.5 mg tid ×4 weeks

    45% abstinence rate

    ​Parkinson’s Disease​

    5 mg bid

    UPDRS↓30%

    Special Populations​

    Renal Impairment: Reduce dose 50% if GFR <30.

    Pediatrics: Ages 12-18 (requires supervision).

    Dosage and Administration

    Formulations​

    Tablets: 2.5 mg (oral).

    Oral Solution: 5 mg/mL

    Dosing Guidelines​

    Use​

    ​Dose​

    ​Duration​

    Smoking Cessation

    2.5 mg tid

    4-12 weeks

    Neuroprotection

    5 mg qd

    Long-term

    Safety Evaluation

    Adverse Reactions​

    ​System​

    ​Incidence​

    ​Management​

    Gastrointestinal

    10%

    Take with food

    Neurological

    5%

    Dose reduction

    Contraindications & Interactions​

    Severe hepatic impairment.

    Pregnancy (Category C).

    Research Progress Green max

    Novel Formulations​

    Transdermal Patch: 24-hour sustained release.

    Orally Disintegrating Tablets: Rapid onset.

    New Indications​

    Alcohol Dependence: Phase II trials.

    Depression: Preclinical evidence.

    Thermopsis

    Please Send me email and you can get more what you want.

    Such as product of  Price, Specification, MOA, MSDS, Flow Chart, Packing details, Shipping Term, Payment Term, after Sale service and so on.

    Our experts will solve them in no time.