Citrus bergamot extract
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Basic information
Product Name: Citrus bergamot extract
Appearance: Brown to yellow powder or granular
Standard Packing: 25kg/drum
Solubility: Dissolve in water and ethanol.
Stability: Coumarins are easily decomposed under light(should be stored away from light)
High temperature accelerates the oxidation of volatile oil
Quality Standard: CP2020,JP,Customer Made
Main active ingredients
The core active ingredients of Citrus bergamot extract include volatile oils, flavonoids, and coumarins, and their efficacy is closely related to the synergistic effect of these ingredients.
|
Ingredient category |
Representative components |
Molecular formula |
CAS |
Proportion of Content |
Main function |
|
Volatile oils |
Limonene |
C₁₀H₁₆ |
5989-27-5 |
35-45% |
Antibacterial and anti anxiety |
|
Linalool |
C₁₀H₁₈O |
78-70-6 |
15-25% |
Calming and anti-inflammatory |
|
|
Flavonoids |
Hesperidin |
C₂₈H₃₄O₁₅ |
520-26-3 |
5-10% |
cardiovascular protection |
|
Neohesperidin |
C₂₈H₃₄O₁₅ |
13241-33-3 |
3-5% |
antiviral |
|
|
Coumarins |
Bergapten |
C₁₂H₈O₄ |
484-20-8 |
0.5-2% |
photosensitization |
High Purity
100% Natural
Compliant with standards
Stable supplying
Quality ensured
Versatile Applications
Application Fields Green max
1. Food Industry
● Natural spices:
※ The main flavor components of Earl Grey tea
※ Candy and pastry additives
※ Functional food:
※ Lipid lowering formula
※ Emotion regulating drinks
2. Daily chemical products
● Perfume industry:
※ Main components of cologne
※ Medium flavoring base
※ Skincare products:
※ Need to remove photosensitive components
※ Oil control and antibacterial formula
3. Medical and Health Care
● Cardiovascular health:
※ Compound with red yeast rice
※ 100-200mg per day
※ Emotional management:
※ aromatherapy
※ Dilute 1-2% for use
Patent Barriers
● EP3289991B1:
Furanocoumarin-free extraction (Italian monopoly)
● US11478422:
Nobiletin sustained-release formulation (new lipid drug)
Future R&D Directions
1. Synthetic Biology:
● Engineered yeast produces bergamottin (lab yield: 0.5g/L)
2. Structural Modification:
● Bergamottin derivatives: Maintain CYP3A4 inhibition without phototoxicity
3. New Clinical Uses:
● NAFLD: Phase II trials show 18% ↓hepatic fat
4. Toxicology:
● Dermal LD50: >5g/kg (rats)
● Phototoxicity: 0.1% bergapten + UVA → Grade II reaction
5. Drug Interactions:
● High-risk combinations:
※ Statins (3-5× ↑blood levels)
※ Antidepressants (serotonin syndrome risk)
Usage Guidelines
1. Application Protocols:
|
Use Case |
Dosage/Concentration |
Precautions |
|
Aromatherapy |
2-4 drops diffusion |
Avoid eye mucosa contact |
|
Skincare |
≤0.4% in formulation |
12-hour post-application sun avoidance |
|
Lipid management |
500-1000mg/day |
Space 6h apart from statins |
2. Contraindications:
● Pregnancy (uterine relaxation risk)
● Absolute ban for photosensitivity disorders
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