Astragaloside A
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Basic information
Product Name: Astragaloside A
IUPAC Name: (3β,6α,16β,20R,24S)-20,24-Epoxy-3-(β-D-xylopyranosyloxy)-16,25-dihydroxy-9,19-cyclolanostane-6-yl β-D-glucopyranoside
CAS No.: 83207-58-3
Molecular Formula: C₄₁H₆₈O₁₄
Physicochemical Properties:
Parameter |
Value/Description |
Appearance |
White crystalline powder |
Melting Point |
295-298°C (decomposition) |
Solubility |
0.5 mg/mL in water, soluble in methanol/ethanol |
logP |
1.2 (amphiphilic) |
Optical Rotation |
[α]²⁵D = +18° (c=1, methanol) |
Quality Standard: CP2020,JP,Customer Made
Specification
Test Items |
Standard |
Astragaloside A (CAS: 83207-58-3) |
98% by HPLC |
Loss on drying |
≤5.0% |
Residue on ignition |
≤5.0% |
Structural Uniqueness
Multi-Organ Protection
Anti-Aging Potential
1.Molecular Target Network
2. Pharmacokinetics
Absorption
Oral bioavailability 5-8% (enhanced after gut microbiota hydrolysis).
Distribution
High concentrations in heart, liver, kidneys (tissue/plasma ratio >10:1).
Metabolism
Hepatic CYP3A4-mediated hydroxylation (active metabolite AS-IV-19-OH).
Excretion
Primarily biliary (90% clearance in 72h).
Clinical Applications
Indications & Protocols
Condition |
Regimen |
Evidence |
Chronic Heart Failure |
10 mg bid ×12 weeks |
↑8% LVEF* |
Liver Fibrosis |
20 mg qd ×6 months |
↓25% FibroScan value |
Diabetic Nephropathy |
5 mg bid (Phase II) |
↓30% proteinuria |
*Randomized double-blind trial (n=300)
Special Populations
Renal Impairment: Reduce dose 50% if GFR <30 mL/min.
Pediatrics: Limited safety data (research use only).
Dosage and Administration
Formulations
Tablets: 5 mg/tablet (β-cyclodextrin inclusion complex).
Injection: 10 mg/2 mL (dilute in glucose).
Nutraceuticals: 2% standardized extract capsules.
Dosing Guidelines
Use |
Dose |
Duration |
Immune Enhancement |
5-10 mg/day |
Long-term |
Anti-Fibrosis |
10-20 mg/day |
3-6 months |
Acute Cardioprotection |
20 mg IV qd |
7-14 days |
Safety Evaluation
Adverse Reactions
System |
Incidence |
Manifestations |
Gastrointestinal |
3% |
Mild bloating |
Hypersensitivity |
0.2% |
Rash |
Blood Pressure |
Rare |
Transient hypotension |
Contraindications & Interactions
Absolute CI:
Active autoimmune diseases (e.g., SLE).
Post-organ transplant (may weaken immunosuppression).
Cautions:CYP3A4 inducers (e.g., rifampin): ↓60% plasma concentration.
Research Progress Green max
Novel Formulations
Nanostructured Lipid Carriers: ↑25% oral bioavailability.
Transdermal Microneedle Patches: For localized fibrosis treatment.
New Indications
Post-COVID Pulmonary Fibrosis: Inhibits TGF-β1 (↓40% lung collagen in animals).
Diabetic Wound Healing: Promotes angiogenesis (↑2× VEGF).
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