Andrographis Extract
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Basic information
Product Name: Andrographis extract
Appearance: Brown to yellow powder or granular
Standard Packing: 25kg/drum
Solubility: Dissolve in water and ethanol.
Source of Andrographis Extract:
Scientific Name: Andrographis paniculata (Acanthaceae family)
Common Names: Chuanxinlian, Yijianxi, Green Chiretta
Medicinal Parts: Whole plant (mainly leaves and stems), extracted after dryingOrigin: Primarily cultivated in southern China, India, and Southeast Asia
Standard: CP2020, JP, Customer Made
Core Active Components
1. Characteristic Compounds
|
Class |
Representative Compounds |
Content Range |
Bioactivity |
|
Diterpene Lactones |
Andrographolide |
2-6% |
Antiviral (viral replicase inhibition) |
|
Neoandrographolide |
0.5-2% |
Hepatoprotective (↓ALT/AST) |
|
|
Flavonoids |
Andrographin |
0.3-1.5% |
Antioxidant (OH· scavenging) |
|
Organic Acids |
Paniculide acid |
0.2-1.2% |
Anti-inflammatory (NF-κB inhibition) |
|
Polysaccharides |
Arabinogalactan (30kDa) |
3-8% |
Immunomodulation (macrophage activation) |
2. Synergistic Effects:
● Andrographolide + zinc: 2× enhanced anti-dengue virus efficacy
● Flavonoids + selenium: Synergistically reduce liver fibrosis markers (35% ↓hyaluronic acid)
High Purity
100% Natural
Compliant with standards
Stable supplying
Quality ensured
Versatile Applications
Application Fields Green max
1. Pharmaceuticals:
● Antiviral: Andrographolide orally disintegrating tablets (pediatric flu treatment)
● Liver Support: Silymarin-andrographis combo (↓cirrhosis incidence)
2. Functional Foods:
● Liver Protection: Extract + curcumin (alcoholic liver injury prevention)
● Immune Boost: Combined with ganoderma polysaccharides (↑NK cell activity)
3. Animal Husbandry:
● Feed Additive: Antibiotic alternative (poultry respiratory disease control)
Future R&D Directions
1. Structural Optimization:
● Andrographolide propylene glycol ester: ↑Oral bioavailability from 12% to 45%
2. Synthetic Biology:
● Yeast-based andrographolide production (lab yield: 0.5g/L)
3. New Clinical Applications:
● NAFLD: Phase II trials show 28% ↓hepatic fat content
Safety Profile
1. Toxicology:
● Acute Toxicity: LD50 >5g/kg (practically non-toxic)
● Genotoxicity: Negative in Ames test
2. Contraindications:
● Pregnancy (uterine stimulation risk)
● Caution in autoimmune disorders
Usage Guidelines
1. Precision Dosing
|
Application |
Daily Dose |
Duration |
Optimal Combinations |
|
Cold Treatment |
600-800 mg |
7-10 days |
Vitamin C |
|
Liver Support |
400 mg bid |
≥3 months |
Silymarin |
|
Immune Enhancement |
300 mg |
Continuous |
Zinc |
2. Precautions:
● Take with meals to minimize GI irritation
● Monitor liver function during long-term use
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